Tag: insulin resistance

~~Call To Action BioMarkers for the Anti-Inflammation ZONE

Call To Action BioMarkers for the Anti-Inflammation ZONE

 A few blogs back I reported on the C-Reactive Protein ( CRP) bloodtest for a measure of the inflammation in our bodies….


A couple of days ago I started reading Dr. Barry Sears book, Anti-Inflammation Zone.

anti inflammation zone pic

Great book….. I found that there are a number of test that can determine the level of inflammation in our bodies… especially what he calls SILENT INFLAMMATION….

What is SILENT INFLAMMATION???? You might say…..

As the name implies…. It’s inflammation in our bodies that does not (YET) cause us pain.

Dr. Sears says that almost all pain comes from inflammation…. And if we don’t have pain now we WILL soon have it ….. IF we have a measure of inflammation in our bodies….

So…. We need it measured so  we can 1. Detect it 2. Do something about it.

Dr. Sears documents in his book 2 PRIMARY BIOMARKERS and 2 SECONDARY markers.

The primary markers are:

  1. Silent Inflammation Profile (SIP): This is the “gold standard” test for silent inflammation.  There is a long writeup about this in his book, but suffice

    to say…it measures the balance of pro-inflammatory eicosanoids and anti-inflammatory eicosanoids by measuring the key fatty acid building blocks in the bloodstream for eicosanoids.  These are the harmones that ultimately control inflammation. The key measure is the ARACHIDONIC ACID (or AA (bad)) against the Eico-sapentaenoic acid (or EPA(good)). This actual number should be around 1.5 to 3.0. The LOWER number is IDEAL.


  2. FASTING Insulin Levels (FIL):

    This is a measure of the insulin resistance in our bodies.  Dr. Sears says that Insulin Resistance is the underlying cause of obesity and type 2 diabetes and is characterized by excess insulin in the bloodstream.  The IDEAL measure of insulin resistance is 5 with good being 10….


    Dr. Sears says he firmly believes that high levels, say above 3.0 for SIP and above 10 for FIL is a solid predictor of your likelihood of developing cancer, Alzheimer’s, and heart disease.

    Two secondary measures of Silent Inflammation are the ratio of Total Triglycerides (TG) to HDL (or good cholesterol) and the measure of C-Reactive Protein (which we’ve discussed in an earlier blog).


    These two tests are usually covered by insurance and are the tests the doctor will likely run without hesitation….. HOWEVER….. when you ask for the SIP and FIL tests, you’ll likely get some flack from your doctor.  Mainly for two reasons….they are expensive and the insurance will “likely NOT “ pay for them….. soooo

    You’ll have to pay for them yourself….


    But…if you’re serious about your health… you’ll do this…

    Your ratio of TG/HDL should be no more than 2 and the CRP level should be no more than 1… or as Dr. Sears puts it….. IDEAL for both of these tests are LESS THAN 1,

    And GOOD is LESS THAN 2…

So…. A word to the wise…… get these tests run the next time you’re in for your physical….


For example…… you have to stay on top of it with your doctors… Last October I went in for my annual physical…. I had written on a note the tests that I wanted run on my blood…

When I got the results….none of the tests I requested were done…… WHY….. the doctor said he forgot about it…

NO OTHER REASON….. He did say I could come back in for another blood draw and he would do it….however I had just spent 3 hours there and I was frustrated….so I didn’t go back….

Now I have some additional tests to request…. Even though I Might have to pay for them…. I’m getting it done….

Remember….SIP is best…. FIL is second best…. The other two (TG/HDL ration and CRP) or lesser valuable tests…..but

If that’s all you can get….. get it done….

Next we’ll talk about how to eat right to correct any silent inflammation issues.




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See you next time.



Jerry and Diane


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